Effect of Oxygen Releasing Oral Gel Compared to Chlorhexidine Gel in the Treatment of Periodontitis

Authors: R. Niveda(1) and Gurumoorthy Kaarthikeyan(1)*
(1) Department of Periodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.

The study is published in the Journal of Pharmaceutical Research Internationalv

The aim of the current study is to compare the effect of oxygen releasing oral gel and chlorhexidine gel in the treatment of periodontitis and the objective was to assess and compare the changes in clinical parameters such as Probing pocket depth, Bleeding on probing, Clinical attachment levels between oxygen releasing oral gel and chlorhexidine gel.

The current pilot study which compares oxygen releasing gel with chlorhexidine gel is a randomised split mouth clinical trial . All the patients included in the study were patients with moderate to severe periodontitis with no systemic diseases, not under any medication non smoking healthy patients. All the patients received supra and sub gingival scaling, pockets on molars with deeper probing depth on either maxillary or mandibular arch and the medication to be received by the patient were allotted randomly. Randomisation was performed using lot method.Oxygen releasing (Blue M gel) and chlorhexidine gel (Hexigel) was applied at the chosen site, patient was recalled for re application and was reassessed for clinical parameters Paired t test was done to compare the mean difference in probing depth in Blue M gel group and Hexigel group.


Within the limitations of the study from the results it is seen that there is a significant difference in reduction in probing pocket depth. The mean difference between the probing depth reduction in group A (Blue®M) from baseline to 6 week was 2.3 and The mean difference probing depth reduction in group B (Hexigel ) from baseline to 6 week was 1.5. Group A showed better potential in probing depth reduction. It emphasises the fact that thorough sub gingival scaling and root planing along with adjuvant topical oxygen therapy aid in reducing the periodontal pockets further research has to be done to assess the effect of oxygen delivering agents in future.

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