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Oxygen-releasing Gel vs 0.2% Chlorhexidine Gel as an Adjuvant to Scaling and Root Planing: A Randomized. Controlled Trial

Another study from India published end of 2022 in the World Journal of Dentistry

By: Shweta Bali 1), Akshay Bhargava 2), Shobhit Arora 3), Priyanka Aggarwal 4), Aruna Nautiyal 5), Deepali Singhal 6)

1,3,4,5) Department of Periodontics and Oral Implantology, Santosh (Deemed to be University), Santosh Dental College, Ghaziabad, Uttar Pradesh, India
2) Department of Prosthodontics and Crown and Bridge, Santosh (Deemed to be University), Santosh Dental College, Ghaziabad, Uttar Pradesh, India
6) Department of Periodontology, Santosh University, Ghaziabad, Uttar Pradesh, India

Aim: To compare and evaluate oxygen-releasing gel vs 0.2% chlorhexidine (CHX) gel as an adjuvant to scaling and root planing (SRP).

Materials and methods: A total of 11 patients (22 sites) with chronic periodontitis were randomly assigned into test and control groups by the flip of a coin method. Pre-op clinical parameters recorded were plaque index (PI), gingival index (GI), probing pocket depth (PPD), and wound healing index (WHI). Post-completion of SRP, the test group (n = 11) received subgingival delivery of oxygen-releasing gel and the control group (n = 11) received 0.2% CHX gel. A periodontal pack and oral hygiene instructions (OHI) were given. Post-op clinical parameters were measured at 1 and 3 months.

Results: The intergroup comparison of test sites (oxygen-releasing gel) with the control sites (0.2% CHX gel) showed a statistically higher significant reduction in test group when compared to control group in periodontal parameters such as PPD (p < 0.0001), clinical attachment level (CAL) (p < 0.0001), WHI (p, 0.0001). However, no statistically significant difference was found in PI and GI between both groups.

Conclusion: Oxygen-releasing gel, when used as a local drug delivery, showed better results when compared to the current gold standard, that is, 0.2% CHX gel in the nonsurgical management of moderately deep pockets in chronic periodontitis.
Nonsurgical periodontal therapy lays the foundation for most periodontal procedures. It also stands a chance of higher acceptability to the patients. Hence whenever the clinical situation is conclusive, oxygen-releasing gel serves to be an excellent local drug delivery alternative.
Oxygen-releasing gel, when used as a local drug delivery agent, showed better results when compared to the current gold standard, that is., 0.2% CHX gel in the nonsurgical management of moderately deep pockets in chronic periodontitis.

Clinical significance: Nonsurgical periodontal therapy lays the foundation for most periodontal procedures. It also stands a chance of higher acceptability to the patients. Hence, whenever the clinical situation is conducive, oxygen-releasing gel serves to be an excellent local drug delivery alternative.

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