Evaluation Of the Effects of Antioxidant Gel onThe Palatal Graft Donor Site -A Randomised Controlled Clinical Trial
Published May7th, 2023 in the Journal of Population Therapeutics & Clinical Pharmacology
By: Bhavana Garapati(1), Jaiganesh Ramamurthy(2)*, Paladugu Devi Navya(3)
(1) Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical sciences(SIMATS), Saveetha University, Chennai.
(2) Professor and Head, Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical sciences(SIMATS), Saveetha University, Chennai.
(3) Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.
Background: Free Gingival Graft is the most effective way to increase the attached gingiva. However, the donor site morbidity is a serious issue following it. Hence to decrease donor site morbidity and promote faster healing a novel antioxidant blue®m gel was used.
Aim: To compare the in vivo effects of the blue®m gel with slow release of oxygen on the healing of donor site.
Materials And Methods: 60 patients undergoing free gingival surgery were included and randomly divided into 2 groups, group 1 (control group) -palatal donor site was covered with AbGelTMalone and, in group 2 (test group)-blue®m gel was applied to the palatal donor site and covered with AbGelTM. Postoperative pain and Wound healing index were calculated at one week and one month.
Results: Immediately After 2 h (immediately after the effect of anesthesia was resolved), no significant difference was found between both groups (p > 0.05). The pain was significantly reduced in both the groups from baseline to 1 week and 1 month (p < 0.05). At one week and After 1 month, there was a significant difference between both groups (p < 0.05). Values from one week to one month (within the groups) in group 1 and group 2 showed a significant difference (p < 0.05). At the 1-week follow-up, there was a statistically significant difference between the groups (p < 0.05). Even at 1 month, a significant difference was found between the groups (p < 0.05).
Conclusion: According to the findings of the present study, using the blue®m oxygen gel as an adjunct to an AbGelTM improves wound healing, stimulates rapid re-epithelization, and relieves postoperative pain compared with the conventional dressing with AbGelTM alone.